proline oxidase การใช้

Proline oxidase, or proline dehydrogenase, functions as the initiator of the proline cycle.
A deficiency of either proline oxidase or pyrroline-5-carboxylate dehydrogenase results in a buildup of proline in the body.
Hyperprolinemia type I is caused by a mutation in the " PRODH " gene, which codes for the enzyme proline oxidase.
"' Hyperprolinemia "', also referred to as "'prolinemia "'or "'prolinuria "', is a condition which occurs when the amino acid proline is not broken down properly by the enzymes proline oxidase or pyrroline-5-carboxylate dehydrogenase, causing a buildup of proline in the body.
Proline metabolism is especially important in nutrient stress because proline is readily available from the breakdown of extracellular matrix ( ECM ), and the degradation of proline through the proline cycle initiated by proline oxidase ( PRODH ), a mitochondrial inner membrane enzyme, can generate ATP . This degradative pathway generates glutamate and alpha-ketoglutarate, products that can play an anaplerotic role for the TCA cycle . The proline cycle is also in a metabolic interlock with the pentose phosphate pathway providing another bioenergetic mechanism.